This MSCA Doctoral Network within the Horizon Europe Framework Programme will create a generalized hybrid machine learning-based digital infrastructure capable of predicting the impact of Renewable Synthetic Fuels (RSF) in energy-intensive industries (EIIS). To do so, it will equip 10 Doctoral Candidates, who will become the next generation of scientists and entrepreneurs with unique expertise at the intersection of combustion science, fluid dynamics, and machine learning (ML).